MDD Treatment Response Evaluation Quiz

When managing major depressive disorder (MDD), assessing response to treatment can be a complex undertaking. Structured clinician- and patient-rated scales have been developed to assist with this task. Test your knowledge on the clinical tools and considerations that can aid your evaluation of treatment response in MDD.


  1. American Psychiatric Association. Practice Guideline for the Treatment of Patients With Major Depressive Disorder. 3rd ed. American Psychiatric Association; 2010.

  2. Yavorsky C, Ballard E, Opler M, Sedway J, Targum SD, Lenderking W. Recommendations for selection and adaptation of rating scales for clinical studies of rapid-acting antidepressants. Front Psychiatry. 2023;14:1135828. doi:10.3389/fpsyt.2023.1135828
  3. Spitzer RL, Kroenke, K, Williams, JB. Validation and utility of a self-report version of PRIME-MD: The PHQ Primary Care study. JAMA. 1999;282(18):1737-1744. doi:10.1001/jama.282.18.1737
  4. McIntyre R, Kennedy S, Bagby RM, Bakish D. Assessing full remission. J Psychiatry Neurosci. 2002;27(4):235-239.
  5. Hamilton M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23(1):56–62. doi:10.1136/jnnp.23.1.56
  6. Bagby RM, Ryder AG, Schuller DR, Marshall MB. The Hamilton Depression Rating Scale: has the gold standard become a lead weight? Am J Psychiatry. 2004;161(12):2163-2177. doi:10.1176/appi.ajp.161.12.2163
  7. Ma S, Yang J, Yang B, et al. The Patient Health Questionnaire-9 vs. the Hamilton Rating Scale for Depression in assessing major depressive disorder. Front Psychiatry. 2021;12:747139. doi:10.3389/fpsyt.2021.747139
  8. Kroenke K, Spitzer RL, Williams JB. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16(9):606-613. doi:10.1046/j.1525-1497.2001.016009606.x
  9. Desseilles M, Witte J, Chang TE, et al. Assessing the adequacy of past antidepressant trials: a clinician’s guide to the Antidepressant Treatment Response Questionnaire (ATRQ). J Clin Psychiatry. 2011;72(8):1152-1154. doi:10.4088/JCP.11ac07225
  10. Chandler GM, Iosifescu DV, Pollack MH, Targum SD, Fava M. RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ). CNS Neurosci Ther. 2010;16(5):322-325. doi:10.1111/j.1755-5949.2009.00102 
  1. Löwe B, Unützer J, Callahan CM, Perkins AJ, Kroenke K. Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care. 2004; 42(12):1194-201. doi:10.1097/00005650-200412000-00006
  2. Morrens J, Mathews M, Popova V, et al. Use of Clinical Global Impressions-Severity (CGI-S) to assess response to antidepressant treatment in patients with treatment-resistant depression. Neuropsychiatr Dis Treat. 2022;18:1127-1132. doi:10.2147/NDT.S358367
  3. McClintock SM, Husain MM, Wisniewski ST, et al. Residual symptoms in depressed outpatients who respond by 50% but do not remit to antidepressant medication. J Clin Psychopharmacol. 2011;31(2):180-186. doi:10.1097/JCP.0b013e31820ebd2c 

This resource is intended for educational purposes only and is intended for US health care professionals. Health care professionals should use independent medical judgment. All decisions regarding patient care must be handled by a health care professional and be made based on the unique needs of each patient.

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Approved 10/2023
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