Quiz on the VAST-D Study

The VA Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) study was a clinical trial designed to elucidate research-based next steps for outpatients with major depressive disorder (MDD) who did not have an adequate response to standard first-step pharmacotherapy.

*CGI-I = Clinical Global Impression Improvement; MAOI = monoamine oxidase inhibitor; NDRI = norepinephrine/dopamine-reuptake inhibitor; QIDS-C16 = 16-item Quick Inventory of Depressive Symptomatology-Clinician Rated; SGA = second-generation antipsychotic; SNRI = serotonin and norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor

References

  1. Mohamed S, Johnson GR, Chen P, et al. Effect of antidepressant switching vs augmentation on remission among patients with major depressive disorder unresponsive to antidepressant treatment: the VAST-D randomized clinical trial. JAMA. 2017;318(2):132-145.

  2. Rush AJ, Trivedi MH, Ibrahim HM, et al. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression [published correction appears in Biol Psychiatry. 2003;54(5):585]. Biol Psychiatry. 2003;54(5):573-583.
  3. Mohamed S, Johnson GR, Sevilimedu V, et al. Impact of concurrent posttraumatic stress disorder on outcomes of antipsychotic augmentation for major depressive disorder with a prior failed treatment: VAST-D randomized clinical trial. J Clin Psychiatry. 2020;81(4):19m13038.  

This resource is intended for educational purposes only and is intended for US healthcare professionals. Healthcare professionals should use independent medical judgment. All decisions regarding patient care must be handled by a healthcare professional and be made based on the unique needs of each patient. 

ABBV-US-01260-MC , V1.0
Approved 06/2023
AbbVie Medical Affairs 

Recommended on NP Psych Navigator

Welcome To NP Psych Navigator

This website is intended for healthcare professionals inside the United States.
Please confirm that you are a healthcare professional inside the US.

No, I am not US Healthcare professional

You are now leaving NP Psych Navigator

Links to sites outside of NP Psych Navigator are provided as a resource to the viewer. AbbVie Inc accepts no responsibility for the content of non-AbbVie linked sites.

Redirect to:

Please to bookmark content