Quiz on the VAST-D Study

The VA Augmentation and Switching Treatments for Improving Depression Outcomes (VAST-D) study was a clinical trial designed to elucidate research-based next steps for outpatients with major depressive disorder (MDD) who did not have an adequate response to standard first-step pharmacotherapy.

*CGI-I = Clinical Global Impression Improvement; MAOI = monoamine oxidase inhibitor; NDRI = norepinephrine/dopamine-reuptake inhibitor; QIDS-C16 = 16-item Quick Inventory of Depressive Symptomatology-Clinician Rated; SGA = second-generation antipsychotic; SNRI = serotonin and norepinephrine reuptake inhibitor; SSRI = selective serotonin reuptake inhibitor


  1. Mohamed S, Johnson GR, Chen P, et al. Effect of antidepressant switching vs augmentation on remission among patients with major depressive disorder unresponsive to antidepressant treatment: the VAST-D randomized clinical trial. JAMA. 2017;318(2):132-145.

  2. Rush AJ, Trivedi MH, Ibrahim HM, et al. The 16-Item Quick Inventory of Depressive Symptomatology (QIDS), clinician rating (QIDS-C), and self-report (QIDS-SR): a psychometric evaluation in patients with chronic major depression [published correction appears in Biol Psychiatry. 2003;54(5):585]. Biol Psychiatry. 2003;54(5):573-583.
  3. Mohamed S, Johnson GR, Sevilimedu V, et al. Impact of concurrent posttraumatic stress disorder on outcomes of antipsychotic augmentation for major depressive disorder with a prior failed treatment: VAST-D randomized clinical trial. J Clin Psychiatry. 2020;81(4):19m13038.  

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