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Predictors of Treatment-Emergent Affective Switch Quiz

Affective switch is a phenomenon that can occur in bipolar I disorder. In particular, affective switch can be triggered by certain medications in what is known as a treatment-emergent affective switch (TEAS), as well as by social and environmental factors. Test your knowledge of the potential symptoms and triggers of affective switch, including TEAS.

References

  1. Salvadore G, Quiroz JA, Machado-Vieira R, Henter ID, Manji HK, Zarate CA. The neurobiology of the switch process in bipolar disorder: a review. J Clin Psychiatry. 2010;71(11):1488-1501. doi:10.4088/JCP.09r05259gre

  2. Muneer A. Mixed states in bipolar disorder: etiology, pathogenesis and treatment. Chonnam Med J. 2017;53:1-13. doi:10.4068/cmj.2017.53.1.1
  3. Vieta E, Angst J, Reed C, Bertsch J, Haro JM; EMBLEM advisory board. Predictors of switching from mania to depression in a large observational study across Europe (EMBLEM). J Affect Disord. 2009;118(1-3):118-123. doi:10.1016/j.jad.2009.02.007
  4. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Text Revision. American Psychiatric Association Publishing; 2022.
  5. Young JW, Dulcis D. Investigating the mechanism(s) underlying switching between states in bipolar disorder. Eur J Pharmacol. 2015;759:151-162. doi:10.1016/j.ejphar.2015.03.019
  6. Maj M, Pirozzi R, Magliano L, et al. The prognostic significance of "switching" in patients with bipolar disorder: a 10-year prospective follow-up study.
    Am J Psychiatry. 2002;159(10):1711-1717. doi:10.1176/appi.ajp.159.10.1711
  7. Yatham LN, Kennedy SH, Parikh SV, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder. Bipolar Disord. 2018;20:97-170. doi:10.1111/bdi.12609
  8. Gitlin MJ. Antidepressants in bipolar depression: an enduring controversy. Int J Bipolar Disord. 2018;6(1):25. doi:10.1186/s40345-018-0133-9
  9. Tondo L, Vázquez G, Baldessarini RJ. Mania associated with antidepressant treatment: comprehensive meta-analytic review. Acta Psychiatr Scand. 2010;121(6):404-14. doi:10.1111/j.1600-0447.2009.01514.x 

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