Mood Disorder Questionnaire (MDQ)

The Mood Disorder Questionnaire (MDQ) is a brief, self-rated questionnaire that can be used to screen patients at risk for bipolar disorder.
Description: The Mood Disorder Questionnaire (MDQ) is a brief, self-rated questionnaire that can be used to screen patients at risk for bipolar disorder.
Disease States: Bipolar disorder
Validated Uses: Screening
Administration Method: Self-report
Time to administer: Less than 5 minutes
Commonly used in: Clinical Practice
Detailed Description: The MDQ is a screening instrument for bipolar disorder that can be administered quickly and easily in primary care settings.2,3 The MDQ is comprised of 13 symptom-specific questions and 2 additional items assessing the co-occurrence of symptoms and functional impairment.1,3 If a patient has a positive screening on the MDQ, the healthcare provider should initiate a comprehensive medical evaluation for bipolar disorder.2,3

A positive screen requires the following criteria be met1,3:

  • “YES” to 7 or more of the 13 items in Question 1; AND
  • “YES” to Question 2; AND
  • “Moderate Problem” or “Serious Problem” to Question 3
Scale Validity: Sensitivity and specificity of the MDQ depend on the population examined. In an outpatient clinic targeting a mood disorder population, the MDQ demonstrated 73% sensitivity and 90% specificity.1,3 In the general population, the MDQ demonstrated 28% sensitivity and 97% specificity.3
Alternative Versions: The MDQ has an adolescent version called the MDQ-A.6 The MDQ-A has both self-report and parent-report versions, with the parent-report version reportedly more useful in detecting possible bipolar disorder.6 The parent-report version (P-MDQ) can also be used in younger pediatric populations.7
Cited Limitations: The MDQ is best at screening for bipolar I disorder (depression and mania) and is not as sensitive to bipolar II disorder (depression and hypomania) or other forms of bipolar disorder (bipolar disorder not otherwise specified).8

Footnotes:

Supporting references for the filters are as follows:
Disease State: Bipolar disorder1-3; Validated Uses: Screening1-4; Administration Method: Self-report1-3; Time to administer: < 5 minutes3,5; Commonly used in: Clinical Practice1-3 
 

This resource is intended for educational purposes only and is intended for US healthcare professionals. Healthcare professionals should use independent medical judgment. All decisions regarding patient care must be handled by a healthcare professional and be made based on the unique needs of each patient. 

 

ABBV-US-01554-MC, Version 1.0 
Approved 03/2024 
AbbVie Medical Affairs 

References:

  1. Hirschfeld RM, Williams JB, Spitzer RL, et al. Development and validation of a screening instrument for bipolar spectrum disorder: the Mood Disorder Questionnaire. Am J Psychiatry. 2000;157(11):1873-1875. doi:10.1176/appi.ajp.157.11.1873 
  2. Hirschfeld RM. The Mood Disorder Questionnaire: a simple, patient-rated screening instrument for bipolar disorder. Prim Care Companion J Clin Psychiatry. 2002;4(1):9-11. doi:10.4088/pcc.v04n0104 
  3. STABLE National Coordinating Council Resource Toolkit Working Group. STABLE Resource Toolkit. Standards for Bipolar Excellence Project; 2015.  
  4. Rush AJ, First MB, Blacker D. Handbook of Psychiatric Measures. American Psychiatric Publishing; 2008. 
  5. Williams N. The MRC breathlessness scale. Occup Med (Lond). 2017;67(2):165-166.9. doi:10.1093/occmed/kqx086 
  6. Wagner KD, Hirschfeld RM, Emslie GJ, et al. Parental report version of the Mood Disorder Questionnaire for adolescents has good sensitivity and specificity for diagnosing bipolar disorder in psychiatric outpatient clinics. J Clin Psychiatry. 2006;67(5):827-830.  
  7. Youngstrom E, Meyers O, Demeter C, et al. Comparing diagnostic checklists for pediatric bipolar disorder in academic and community mental health settings. Bipolar Disord. 2005;7:507-517. doi:10.1111/j.1399-5618.2005.00269.x 
  8. Miller C, Klugman J, Berv DA, Rosenquist KJ, Ghaemi SN. Sensitivity and specificity of the Mood Disorder Questionnaire for detecting bipolar disorder. J Affect Disord. 2004;81(2):167-171. doi:10.1016/S0165-0327(03)00156-3

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